Using Multiple Continuous Biomarkers for Patient Enrichment in Two-Stage Clinical Designs


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Documentation for package ‘cobenrich’ version 1.0.1

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avetrteff2 Compute the average subpopulation treatment effect and the standardized average subpopulation treatment effect when two biomarkers are involved
findATE2 Find the cutoff values of biomarkers based on the average subpopulation treatment effect
findSATE2 Find the cutoff values of biomarkers based on the standardized average subpopulation treatment effect
targetDel Find the difference between the average subpopulation treatment effect and the desired one
targetLam Find the difference between the standardized average subpopulation treatment effect and the desired one